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O que (quem) é métallo - definição
New Delhi metallo-beta-lactamase 1
CHEMICAL COMPOUND
NDM-1; Ndm1; New Delhi metallo-b-lactamase; New Delhi metallo beta-lactamase; New Delhi metallo betalactamase; New Delhi metallobetalactamase; New Delhi metallo-β-Lactamase; NDM 1; South Asian Superbug; New Delhi metallo-lactamase-1; Indian superbug; New Delhi metallo-beta-lactamase; Plasmid-encoding Carbapenemase-resistant Metallo-B-Lactamase
NDM-1 is an enzyme that makes bacteria resistant to a broad range of beta-lactam antibiotics. These include the antibiotics of the carbapenem family, which are a mainstay for the treatment of antibiotic-resistant bacterial infections.
DNA-binding metallo-intercalators
![Figure 2: Metallo-intercalators enter double stranded DNA via the major groove and π-stack between adjacent unbroken base pairs. Here, the phi ligand of a rhodium complex intercalates a DNA segment with the sequence 5'-G(5IU)TGCAAC-3' (PDB ID 454D).<ref name="ref9">Kielkopf, C. L., K. E. Erkkila, B. P. Hudson, J. K. Barton, and D. C. Rees. "INTERCALATION AND MAJOR GROOVE RECOGNITION IN THE 1.2 A RESOLUTION CRYSTAL STRUCTURE OF RH[ME2TRIEN]PHI BOUND TO 5'-G(5IU)TGCAAC-3'" RCSB Protein Data Bank. N.p., n.d. Web. 26 Jan. 2015. <http://www.rcsb.org/pdb/explore/explore.do?structureId=454D>.</ref>](https://commons.wikimedia.org/wiki/Special:FilePath/Metallo-intercalator DNA binding.png?width=200 "Figure 2: Metallo-intercalators enter double stranded DNA via the major groove and π-stack between adjacent unbroken base pairs. Here, the phi ligand of a rhodium complex intercalates a DNA segment with the sequence 5'-G(5IU)TGCAAC-3' (PDB ID 454D).<ref name=\"ref9\">Kielkopf, C. L., K. E. Erkkila, B. P. Hudson, J. K. Barton, and D. C. Rees. \"INTERCALATION AND MAJOR GROOVE RECOGNITION IN THE 1.2 A RESOLUTION CRYSTAL STRUCTURE OF RH[ME2TRIEN]PHI BOUND TO 5'-G(5IU)TGCAAC-3'\" RCSB Protein Data Bank. N.p., n.d. Web. 26 Jan. 2015. <http://www.rcsb.org/pdb/explore/explore.do?structureId=454D>.</ref>")
![Figure 1: Chemical structure of the DNA-binding metallo-intercalator complex [Ru(bpy)2(paip)]2+ with intercalative and ancillary ligands labeled.<ref name="ref6"/><ref name="ref7"/>](https://commons.wikimedia.org/wiki/Special:FilePath/Ru(bpy)2(paip)2+.png?width=200 "Figure 1: Chemical structure of the DNA-binding metallo-intercalator complex [Ru(bpy)2(paip)]2+ with intercalative and ancillary ligands labeled.<ref name=\"ref6\"/><ref name=\"ref7\"/>")
DNA-binding metallo-intercalators are positively charged, planar, polycyclic, aromatic compounds that unwind the DNA double helix and insert themselves between DNA base pairs. Metallo-intercalators insert themselves between two intact base pairs without expelling or replacing the original nitrogenous bases; the hydrogen bonds between the nitrogenous bases at the site of intercalation remain unbroken.
Metallo-ene reaction
The metallo-ene reaction is a chemical reaction employed within organic synthesis. Mechanistically similar to the classic ene reaction, the metallo-ene reaction involves a six-member cyclic transition state that brings an allylic species and an alkene species together to undergo a rearrangement.
